2022Aug02: An increasing number of users reported problems to download ANNOVAR databases from institutional computing clusters. This is due to automated re-direction of http traffic to https, and that ANNOVAR server's https (which uses a free service) is not recognized as valid by some institutions. For this reason, the download URL that uses http will no longer be re-directed to https traffic in ANNOVAR server; this is the easiest way to ensure backward compatibility for users. If you absolutely need to use https for any reason, you can edit the source code of ANNOVAR to use https in the URL.
2021Jan27: The ANNOVAR annotation databases are being moved to a new hosting server. We plan to still keep the old S3-based server as a CDN for Asia and Middle East to improve download speed; you can explicitly specify www2 (instead of default www) in the -downdb command line.
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2019Dec03: ANNOVAR download consistently exceeds >10TB/month over the past two months and the cost for hosting it at AWS is absurdly high (unfortunately currently no grant funding is available to support ANNOVAR). During the next a few days, I will migrate ANNOVAR out of AWS to a new CDN provider and test it over the next two months. Expect some connection issues when you do -downdb depending on your geographical locations over the next a few days. (Update 2019Dec06: Migration is completed successfully, please report issues if you encounter any).
2019Nov27: A slight change was made to coding_change.pl to fix the 'argument G is not numeric in numeric gt (>)' bug for startloss mutations, and you can download the updated file here. Please report additioanl bugs on the 2019Oct24 version to me if you find any.
2019Nov01: gene4denovo annotation database with 580K de novo mutations for hg19/hg38 are available in ANNOVAR (use hg19_gene4denovo201907 and hg38_gene4denovo201907 keywords to download). Read here for more information.
May 2019: We are in the process of moving ANNOVAR server to a different hosting vendor. There is no need to email me about the -downdb problem. If you have an urgent need for the software itself, you can email me to get a URL link to download, but the DB will not be available for a few days.
2018Mar25: pre-computed intervar scores (version 20180118) is available on both hg19 and hg38 now with intervar_20180118 keyword. Only missense variants are included, and this is meant for a quick-and-dirty analysis of most missense variants. For a more comprehensive/formal calculation of scores, download instead.
2018Mar02: About 2.4 million Brazilian genomic variants with allele frequencies are available now in hg19/hg38 coordinate. The data set comprises exomic variants of 609 elderly individuals from a census-based sample from the city of São Paulo. Please use abraom as the keyword to download and annotate, and refer to the original publication for details.
2017Jul16: ANNOVAR new version is available now! You can use the old link to download, or you can register again to get download email. This release contins some minor fixes and improvements: fixed a bug in calculating upstream distance that print when -separate is specified in annotate_variation.pl, improvements to coding_change.pl to report more stopgain/stoploss and fix use-of-uninitialized-value issue, slight change to convert2annovar.pl to handle mal-formed VCF file.
2017Jun01: ANNOVAR new version is available now! You can use the old link to download, or you can register again to get download email. Important features include: gx operation is added in table_annovar so that xref information for genes (such as gene-disease relationships) can be included (see quick start-up for examples), show complete amino acid change (such as c.35delG:p.G12Vfs*2) in gene annotaion in table_annovar.pl and coding_change.pl with -polish argument, upstream variants now show distance to transcriptional start, splice variants at UTR now shows details, etc. (Update 2017Jun08: some users complained about format change in 2017jun01 version of table_annovar, where semicolon was used instead of comma for gene-based annotation, we have now reverted this change. Additional feature for -xreffile with multiple annotation columns has been implemented. Please re-download the code)
2017Jun01: Updated refGene, knownGene, ensGene definition and FASTA file on hg18/hg19/hg38 coordinates are available to download with -webfrom annovar argument. However, users can always build the latest version yourself.
2017Feb02: InterVar automated prediction is available for clinical interpretation of missense variants, with 18 criteria based on 2015 ACMG-AMP guidelines. Use intervar_20170202 keyword to download and use. Read the InterVar paper for details.
2016Oct24: GME (Greater Middle East Variome) is available to download from ANNOVAR now with keyword gme. It contains allele frequency data on NWA (northwest Africa), NEA (northeast Africa), AP (Arabian peninsula), Israel, SD (Syrian desert), TP (Turkish peninsula) and CA (Central Asia).
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